- THE MONNALISA TOUCH
- ENDOSCOPIC SURGERY
- VERIFICATION OF INFERTILITY
- NEXPLANON
- ONCOLOGICAL SCREENING
- PRENATAL DIAGNOSIS
- DIAGNOSTIC ULTRASOUND
- FUNCTIONAL COSMETIC GYNECOLOGICAL SURGERY
- TREATMENT OF STRESS URINARY INCONTINENCE (SUI)
NEWS
CLINICAL AND VAGINAL MICROBIOTA EFFECTS OF ORAL LACTOBACILLUS CRISPATUS M247 COMBINED WITH VAGINAL LASER THERAPY IN MENOPAUSAL WOMEN WITH ATROPHIC VULVOVAGINITIS: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY
Laser in Medical Science 2026
The study evaluates the effect of vaginal CO₂ laser treatment, combined or not, with an oral probiotic containing Lactobacillus crispatus M247 in postmenopausal women with vulvovaginal atrophy/GSM.
The combination of microfractionated CO₂ laser treatment and the oral probiotic L. crispatus M247 appears to offer additional benefits compared to laser treatment alone, especially for vaginal symptoms and microbiota profile, although the results should be interpreted with caution due to methodological limitations.
This was a prospective, randomized, controlled, open-label, multicenter study in which 75 postmenopausal women with VVA/GSM, randomized 2:1, underwent three sessions of microfractionated CO₂ laser (MonaLisa Touch) four weeks apart, with a 90-day follow-up.
• CO₂ laser alone (50 patients)
• CO₂ laser + oral probiotic (L. crispatus M247 for 90 days) (25 patients)
Both treatments in the two groups resulted in a significant reduction in GSM symptoms, although the laser + probiotic group
showed better results.
The most interesting result is the change in the microbiota.
This suggests that the probiotic enhances the reconstitution of the vaginal ecosystem, not just symptomatic control.
The microfractionated CO₂ laser improves GSM/VVA symptoms; the addition of L. crispatus M247 appears to amplify the clinical benefit and promote the restoration of a more physiological vaginal microbiota, suggesting a possible integrated “tissue + microbiota oriented” approach.
Download the article
Laser in Medical Science 2026
The study evaluates the effect of vaginal CO₂ laser treatment, combined or not, with an oral probiotic containing Lactobacillus crispatus M247 in postmenopausal women with vulvovaginal atrophy/GSM.
The combination of microfractionated CO₂ laser treatment and the oral probiotic L. crispatus M247 appears to offer additional benefits compared to laser treatment alone, especially for vaginal symptoms and microbiota profile, although the results should be interpreted with caution due to methodological limitations.
This was a prospective, randomized, controlled, open-label, multicenter study in which 75 postmenopausal women with VVA/GSM, randomized 2:1, underwent three sessions of microfractionated CO₂ laser (MonaLisa Touch) four weeks apart, with a 90-day follow-up.
• CO₂ laser alone (50 patients)
• CO₂ laser + oral probiotic (L. crispatus M247 for 90 days) (25 patients)
Both treatments in the two groups resulted in a significant reduction in GSM symptoms, although the laser + probiotic group
showed better results.
The most interesting result is the change in the microbiota.
This suggests that the probiotic enhances the reconstitution of the vaginal ecosystem, not just symptomatic control.
The microfractionated CO₂ laser improves GSM/VVA symptoms; the addition of L. crispatus M247 appears to amplify the clinical benefit and promote the restoration of a more physiological vaginal microbiota, suggesting a possible integrated “tissue + microbiota oriented” approach.
Download the article
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CLINICAL AND VAGINAL MICROBIOTA EFFECTS OF ORAL LACTOBACILLUS CRISPATUS M247 COMBINED WITH VAGINAL LASER THERAPY IN MENOPAUSAL WOMEN WITH ATROPHIC VULVOVAGINITIS: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY
The study evaluates the effect of vaginal COâ‚‚ laser treatment combined or not read more
CLINICAL AND VAGINAL MICROBIOTA EFFECTS OF ORAL LACTOBACILLUS CRISPATUS M247 COMBINED WITH VAGINAL LASER THERAPY IN MENOPAUSAL WOMEN WITH ATROPHIC VULVOVAGINITIS: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY
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For over 33 years CO2 laser activity has always been a high-tech treatment that read more
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On 25.10.2024 Dr. Filippini conducted a day of theoretical-practical training a read more
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Article published in the MDPI Journal of Personalized Medicine which evaluates t read more
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On 2023.11.02 Dr. Filippini held a course on the new laser and electromagnetic t read more
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On Monday 29 May 2023 in the lecture hall of the Secretariat of the University read more
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Intensive theoretical and practical courses individuals or small groups on the read more
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